Cells Molecules and Mechanisms
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Key areas of investigation are the identification and functional characterization of stem cell niches in developing tissues and adult organs. This research aims at characterizing molecules and signals involved in controlling the undifferentiated state and self-renewal capacity of stem cells, and to develop methods to direct the differentiation of stem cells into clinically relevant cell types. Extensive emphasis is also made on tissue differentiation and growth during embryogenesis, and deciphering mechanisms underlying the establishment cellular diversity in developing tissues and organs.
Many of these questions are addressed in studies of the developing nervous system and in the mature brain. A wide range of technical platforms and model organisms are applied to pursue relevant research topics. Basic genetic and molecular biology methodologies are combined with complementary bioinformatic and genome-wide approaches, allowing investigation global molecular changes in cells in various differentiation processes.
The aim of the Infection and Cancer theme is to study how latent viral infections and chronic bacterial infections are associated with the development of cancer. Common infectious diseases remain a major cause of morbidity and mortality worldwide. This is illustrated by the emergence of antibiotic resistant bacteria, and highly pathogenic viruses, such as HIV, SARS and new strains of influenza.
In addition, infections contribute or are suspected to contribute to a surprisingly broad spectrum of malignancies. We are focusing on the pathogen-host interaction at the cellular, tissue and organism levels, and are interested in understanding how this interaction alters processes involved in the regulation of genomic stability, cell cycle progression, cell death, and cellular and tissue re-modelling.
Physiological Abnormalities, Diseases and Interventions
The models used in our research are: the lymphotropic Epstein-Barr virus EBV and bacteria producing the cytolethal distending toxin CDT , a bacterial genotoxin. EBV has a dual life cycle characterized by the establishment of latency in B-lymphocytes and productive infection in epithelial cells. Latently infected B-cells express a restricted set of viral genes that promote a global rearrangement of the cellular environment leading to B-cell growth transformation and immortalization. TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Martinon, F. NALP inflammasomes: a central role in innate immunity. Kalai, M. Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Ma, Y. Francois, M. Koterski, J. Virulent Shigella flexneri causes damage to mitochondria and triggers necrosis in infected human monocyte-derived macrophages.
Willingham, S. Cell Host Microbe 2 , — Chu, J. The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose. Ray, C. The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the CrmA gene. Virology , — A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Micheau, O. Induction of TNF receptor I- mediated apoptosis via two sequential signaling complexes. Deveraux, Q. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
EMBO J. Csomos, R. Rothe, M. Cell 83 , — Bertrand, M. Cell 30 , — Wong, W. Ea, C. Cell 22 , — Christofferson, D. Necroptosis as an alternative form of programmed cell death. Ting, A. Shembade, N. Enesa, K. Xu, G.
Feng, S. Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal 19 , — Wang, L. Lin, Y. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. Ermolaeva, M.
Declercq, W. RIP kinases at the crossroads of cell death and survival. Vandenabeele, P. Caspase inhibitors promote alternative cell death pathways. STKE , pe44 Sun, X.
Cellular and molecular mechanisms of repair in acute and chronic wound healing - Semantic Scholar
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein RIP by RIP3. Kelliher, M.
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Immunity 8 , — Identification of RIP1 kinase as a specific cellular target of necrostatins. Teng, X. Structure—activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors.
Necrotic cell death and 'necrostatins': now we can control cellular explosion. Trends Biochem. Upton, J. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 7 , — Soldani, C. Poly ADP-ribose polymerase-1 cleavage during apoptosis: an update. Apoptosis 7 , — Saelens, X. Protein synthesis persists during necrotic cell death.
Caspase activation inhibits proteasome function during apoptosis. Cell 14 , 81—93 Leist, M. Intracellular adenosine triphosphate ATP concentration: a switch in the decision between apoptosis and necrosis.
Kraus, W. Transcriptional control by PARP chromatin modulation, enhancer-binding, coregulation, and insulation.
Los, M. Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Cell 13 , — Yu, S.